Non-steroidal Anti-inflammatory Drugs Stimulate Secretion of Non-amyloidogenic Precursor Protein

Non-steroidal anti-inflammatory drugs stimulate secretion of non-amyloidogenic precursor protein.

Chronic inflammatory processes are associated with the pathophysiology of Alzheimer's disease (AD), and it has been proposed that treatment with non-steroidal anti-inflammatory drugs (NSAIDs) reduces the risk for AD. Here we report that various NSAIDs, such as the cyclooxygenase inhibitors, nimesulide, ibuprofen and indomethacin, as well as thalidomide (Thal) and its non-teratogenic analogue, s...

Non-steroidal anti-inflammatory drugs.

Safety of non-steroidal anti-inflammatory drugs.

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in medical practice for treating pain, inflammation and degenerative joint diseases (for instance, arthritis). The use of traditional NSAIDs (tNSAIDs), however, is associated with an increased risk of minor and serious gastrointestinal (GI) events. It is estimated that in the European Union thousands of gastrointestinal complication...

[Non-steroidal anti-inflammatory drugs (NSAIDs)].

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[Non-steroidal anti-inflammatory drugs (NSAID)].